| 12:00 PM ET | Tarleton State Texans @ Bowling Green Falcons | -2.5 | 47.5 | 98% | 56% | 78% | +22.2pp LEAN · FCS |
| 2:00 PM ET | Rhode Island Rams @ Temple Owls | -10.5 | 51.5 | 97% | 79% | 88% | +9.5pp LEAN · FCS |
| 7:00 PM ET | Idaho State Bengals @ Utah State Aggies | -12.8 | 62 | 98% | 81% | 90% | +9.2pp LEAN · FCS |
| 8:00 PM ET | South Dakota State Jackrabbits @ Northwestern Wildcats | -13 | 46.5 | 99% | 83% | 92% | +9.1pp LEAN · FCS |
| 12:00 PM ET | Liberty Flames @ James Madison Dukes | -7 | 52.5 | 88% | 69% | 76% | +6.9pp LEAN |
| 12:00 PM ET | Oregon State Beavers @ Houston Cougars | -20.5 | 51 | 83% | 91% | 89% | — |
| 12:00 PM ET | Coastal Carolina Chanticleers @ West Virginia Mountaineers | -21.5 | 56.5 | 65% | 91% | 86% | — |
| 12:00 PM ET | East Carolina Pirates @ Alabama Crimson Tide | -28.5 | 54 | 81% | 96% | 93% | — |
| 12:00 PM ET | Lafayette Leopards @ UConn Huskies | -19 | 57.5 | 99% | 90% | 95% | — |
| 12:00 PM ET | Ohio Bobcats @ Nebraska Cornhuskers | -23.5 | 47.5 | 48% | 93% | 86% | — |
| 12:30 PM ET | Miami (OH) RedHawks @ Pittsburgh Panthers | -16.5 | 49.5 | 69% | 85% | 81% | — |
| 12:45 PM ET | Kent State Golden Flashes @ South Carolina Gamecocks | -36.5 | 54 | 87% | 97% | 95% | — |
| 1:00 PM ET | Southeast Missouri State Redhawks @ Iowa State Cyclones | -30.5 | 52.5 | 99% | 97% | 98% | — |
| 1:00 PM ET | Duquesne Dukes @ Air Force Falcons | -28.8 | 57.8 | 98% | 96% | 97% | — |
| 3:30 PM ET | Boston College Eagles @ Cincinnati Bearcats | -7.5 | 51.5 | 71% | 72% | 72% | — |
| 3:30 PM ET | Tulane Green Wave @ Duke Blue Devils | -9.5 | 51 | 59% | 75% | 71% | — |
| 3:30 PM ET | Baylor Bears @ Auburn Tigers | -7 | 59 | 62% | 71% | 68% | — |
| 3:30 PM ET | UT Rio Grande Valley Vaqueros @ UTSA Roadrunners | -29.5 | 59.5 | 99% | 96% | 97% | — |
| 3:30 PM ET | Boise State Broncos @ Oregon Ducks | -24.5 | 52 | 84% | 94% | 91% | — |
| 3:30 PM ET | Marshall Thundering Herd @ Penn State Nittany Lions | -24.5 | 54.5 | 82% | 93% | 91% | — |
| 3:30 PM ET | Texas State Bobcats @ Texas Longhorns | -30.5 | 60 | 85% | 96% | 94% | — |
| 3:45 PM ET | Oklahoma State Cowboys @ Tulsa Golden Hurricane | +14 | 59.5 | 58% | 18% | 28% | — |
| 6:00 PM ET | Wyoming Cowboys @ Colorado State Rams | -3.5 | 47.5 | 58% | 60% | 59% | — |
| 7:00 PM ET | Arkansas State Red Wolves @ Memphis Tigers | -9.5 | 53.5 | 74% | 75% | 75% | — |
| 7:00 PM ET | Florida International Panthers @ South Florida Bulls | -13.5 | 54 | 79% | 81% | 80% | — |
| 7:00 PM ET | Murray State Racers @ Middle Tennessee Blue Raiders | -20.8 | 59.5 | 96% | 91% | 93% | — |
| 7:00 PM ET | Eastern Kentucky Colonels @ Jacksonville State Gamecocks | -20.5 | 54.5 | 99% | 91% | 95% | — |
| 7:00 PM ET | Austin Peay Governors @ Vanderbilt Commodores | -30.3 | 61 | 99% | 97% | 98% | — |
| 7:00 PM ET | Charleston Southern Buccaneers @ Georgia Southern Eagles | -27 | 51.5 | 99% | 95% | 97% | — |
| 7:30 PM ET | Clemson Tigers @ LSU Tigers | -10.5 | 51 | 58% | 77% | 72% | — |
| 7:30 PM ET | Western Michigan Broncos @ Michigan Wolverines | -27.5 | 48.5 | 79% | 94% | 91% | — |
| 7:30 PM ET | UL Monroe Warhawks @ Mississippi State Bulldogs | -28.5 | 55.5 | 78% | 95% | 92% | — |
| 7:45 PM ET | Florida Atlantic Owls @ Florida Gators | -27 | 59.5 | 82% | 94% | 92% | — |
| 8:00 PM ET | Lamar Cardinals @ Louisiana Ragin' Cajuns | -20.5 | 49 | 99% | 91% | 95% | — |
| 9:00 PM ET | Mercyhurst Lakers @ New Mexico State Aggies | -28.5 | 51.5 | 97% | 96% | 96% | — |
| 9:30 PM ET | Northern Arizona Lumberjacks @ Arizona Wildcats | -33.5 | 57.5 | 99% | 97% | 98% | — |
| 10:00 PM ET | UNLV Rebels @ Hawai'i Rainbow Warriors | +3 | 58.3 | 50% | 42% | 45% | — |
| 10:00 PM ET | Central Michigan Chippewas @ New Mexico Lobos | -10.5 | 46.5 | 74% | 78% | 77% | — |
| 10:30 PM ET | UCLA Bruins @ California Golden Bears | +1.5 | 53.5 | 63% | 47% | 52% | — |
| 10:30 PM ET | Western Kentucky Hilltoppers @ Nevada Wolf Pack | +2.5 | 52.5 | 37% | 44% | 42% | — |